Ammonia → HCID 12788083, compound

HRID 1732896Notes

Reaction equation

HRID 1732896 reaction equation
C([O:3][C:4](=O)[CH2:5][O:6][CH2:7][C:8]1[S:9][C:10]([CH2:13][N:14]([CH3:16])[CH3:15])=[CH:11][CH:12]=1)C.[NH3:18]>C(O)C>[CH3:15][N:14]([CH2:13][C:10]1[S:9][C:8]([CH2:7][O:6][CH2:5][C:4]([NH2:18])=[O:3])=[CH:12][CH:11]=1)[CH3:16]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 12788082HCID 12788082, compound

Product 1

HCID 12788083HCID 12788083, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of [[5-(N,N-dimethylaminomethyl)2-thienyl]methoxy] acetic acid ethyl ester (4.0 g) in a mixture of 0.88 ammonia solution (75 ml) and ethanol (75 ml) was stirred for 1 hr at room temperature. The solvent was removed and the residue recrystallised from a 1:1 mixture of benzene and petroleum spirit (b.p. 60°-80°) to afford a white crystalline solid (3.2 g) m.p. 86.5°-95°. NMR (CDCl3) 7.71, s, (6H); 6.38, s, (2H); 6.00, s, (2H); 5.30, s, (2H); 3.5, br, (2H); 3.12, q, (2H).

Workup

  1. customThe solvent was removed
  2. customthe residue recrystallised from a 1:1 mixture of benzene and petroleum spirit (b.p. 60°-80°)

Sources & evidence

ORD record
ord-55d91735dca14a72904f46d886d10b16
Source dataset
uspto-grants-1980_12
Patent number
US04239769

Reaction notes

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