HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid monohydrate → 6-Bromo-2-cyclopropyl-7-fluoro-5-methylbenzoxazole-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | 2-Amino-5-bromo-3-cyano-6-fluoro-4-methylphenyl acetate | HCID 86097516 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 6-Bromo-2-cyclopropyl-7-fluoro-5-methylbenzoxazole-4-carbonitrile | HCID 51041427 | — |
Reaction Steps
2-Amino-5-bromo-3-cyano-6-fluoro-4-methylphenyl acetate (I-76) (7.95 g, 25.38 mmol) was dissolved in toluene (80 ml), p-toluenesulfonic acid monohydrate (1.60 g, 20 wt. %) was added, followed by stirring under reflux for 19 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07737166B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-c5a4eb7304a7465ea090a9d1fd91deef |
| Source note | uspto-grants-2010_06 |