HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzeneacetonitrile, alpha-hydroxy-3-phenoxy-, (alphaS)- → Flucythrinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzeneacetonitrile, alpha-hydroxy-3-phenoxy-, (alphaS)- | HCID 93218 | — |
| Reactant | 2-(4-Difluoromethoxyphenyl)-3-methylbutyryl chloride | HCID 13118567 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Flucythrinate | HCID 50980 | — |
Reaction Steps
A method for the preparation of the compound (-)-α-cyano-m-phenoxybenzyl (+)-α-isopropyl-4-difluorophenylacetate comprising: reacting (+)-α-isopropyl-4-difluoromethoxyphenylacetyl chloride with α-cyano-m-phenoxybenzyl alcohol in the presence of pyridine and isolating from the thus-obtained mixture of (+)-α-cyano-m-phenoxybenzyl (+)-α-isopropyl-4-difluoromethoxyphenylacetate said (-)-α-cyano-m-phenoxybenzyl (+)-α-isopropyl-4-difluoromethoxyphenylacetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04239777 |
| Source dataset | uspto-grants-1980_12 |
| ORD ID | ord-537305674d12425897bbfae669644702 |
| Source note | uspto-grants-1980_12 |