4-Chloro-7-methyl-1,2,3-triazino[4',5'-4,5]thiopheno[2,3-b]pyridine → HCID 178422890, compound

HRID 1732919Notes

Reaction equation

HRID 1732919 reaction equation
Cl[C:2]1[C:3]2[S:10][C:9]3[N:11]=[C:12]([CH3:15])[CH:13]=[CH:14][C:8]=3[C:4]=2[N:5]=[N:6][N:7]=1.NC(N)=[S:18]>C(O)C>[SH:18][C:2]1[C:3]2[S:10][C:9]3[N:11]=[C:12]([CH3:15])[CH:13]=[CH:14][C:8]=3[C:4]=2[N:5]=[N:6][N:7]=1

Participants

4

Reactant 2

HCID 4607114-Chloro-7-methyl-1,2,3-triazino[4',5'-4,5]thiopheno[2,3-b]pyridineHCID 2723790Thiourea

Product 1

HCID 178422890HCID 178422890, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 7 g. (0.03 M) of 4-chloro-7-methylpyrido[3',2':4,5]thieno[3,2-d]-1,2,3-triazine, and 7 g. (0.09 M) of thiourea in 350 ml. ethanol was refluxed for 2 hours. It was then cooled and filtered. The crude product was dissolved in 5% NaOH, and treated with charcoal and filtered. Acidification with HOAC followed by filtration yielded yellow solid, m.p. 205°-208° C.

Workup

  1. additionA mixture of 7 g
  2. temperatureIt was then cooled
  3. filtrationfiltered
  4. dissolutionThe crude product was dissolved in 5% NaOH
  5. additiontreated with charcoal
  6. filtrationfiltered
  7. filtrationAcidification with HOAC followed by filtration
  8. customyielded yellow solid, m.p. 205°-208° C.

Sources & evidence

ORD record
ord-c613b96f6a9845928a6191d94881322a
Source dataset
uspto-grants-1980_12
Patent number
US04239887

Reaction notes

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