Formic Acid → HCID 20303354, compound

HRID 1732925Notes

Reaction equation

HRID 1732925 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:12][N:11]=[C:10]([C:13]([OH:15])=[O:14])[CH:9]=1.[CH:16](O)=O>O>[CH:9]1[C:10]([C:13]([OH:15])=[O:14])=[N:11][N:12]2[C:8]=1[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[N:1]=[CH:16]2

Participants

4

Reactant 2

HCID 284Formic AcidHCID 178507483HCID 178507483, compound

Product 1

HCID 20303354HCID 20303354, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3.0 g (0.0148 mole) of 5-(2-aminophenyl)-1H-pyrazole-3-carboxylic acid is suspended in 21 ml of 97+% HCOOH, and the reaction mixture heated in an oil bath at 100° for 2 hours. The reaction mixture is cooled, diluted with water (75 ml), stirred for 30 minutes and filtered, washing the precipitates well with water. The crude product is dried overnight in vacuo at 90°. Yield: 2.9 g. Percent crude yield: 91.8%.

Workup

  1. temperaturethe reaction mixture heated in an oil bath at 100° for 2 hours
  2. temperatureThe reaction mixture is cooled
  3. filtrationfiltered
  4. washwashing the
  5. customprecipitates well with water
  6. dry with materialThe crude product is dried overnight in vacuo at 90°

Sources & evidence

ORD record
ord-c7521aa562644ae78bcb5deafbe8f432
Source dataset
uspto-grants-1980_12
Patent number
US04239896

Reaction notes

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