Acetic Anhydride → HCID 70591618, compound

Participants

Reaction Steps

When 7-methyl-thieno[3,4-b][1,5]benzoxazepin-10-(9H)-one is refluxed for 16 hours in 5 N sodium hydroxide, diluted with water, adjusted to pH 4-5 with dilute hydrochloric acid and extracted with methylene chloride, 4-(2-amino-p-tolyloxy)-3-thiophenecarboxylic acid (IX) is obtained. Compound IX is treated with acetic anhydride and extracted with ether to give 4-(2-acetamido-p-tolyloxy)-3-thiophenecarboxylic acid (X). When a stirred mixture of X and lithium aluminum hydride in ether is refluxed for 16 hours and the resulting product is dissolved in ether and treated with alcoholic hydrochloric acid, the compound 4-(2-ethylamino-p-tolyloxy)-3-thiophenemethanol hydrochloride (XI) is obtained.

Provenance & Evidence