Sulfuryl chloride → 4-methoxythiophene-3-carboxamide

HRID 1732938Notes

Reaction equation

HRID 1732938 reaction equation
[CH3:1][O:2][CH:3]1[C:7]([C:8]([NH2:10])=[O:9])=[CH:6][S:5][CH2:4]1.S(Cl)(Cl)(=O)=O>C(Cl)(Cl)(Cl)Cl>[CH3:1][O:2][C:3]1[C:7]([C:8]([NH2:10])=[O:9])=[CH:6][S:5][CH:4]=1

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 54557708HCID 54557708, compound

Product 1

HCID 27785004-methoxythiophene-3-carboxamideYield 75%

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

1.59 Parts of 3-methoxy-dihydrothiophene-4-carboxylic acid amide are reacted with 0.88 part by volume of sulfuryl chloride in 25 parts by volume of carbon tetrachloride in the course of 2 hours at 0° C. The end product is isolated from the reaction mixture by the method described in Example 1c. 1.17 parts (75% of theory) of 3-methoxythiophene-4-carboxylic acid amide are obtained.

Workup

  1. customThe end product is isolated from the reaction mixture by the method

Sources & evidence

ORD record
ord-c313382b724a41108f46c079fb6aad41
Source dataset
uspto-grants-1980_12
Patent number
US04239897

Reaction notes

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