HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuryl chloride → Methyl 4-acetoxythiophene-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | 3-Acetoxy-dihydrothiophene-4-carboxylic acid methyl ester | HCID 54246572 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | Methyl 4-acetoxythiophene-3-carboxylate | HCID 12520003 | 91% |
Reaction Steps
4.04 Parts of 3-acetoxy-dihydrothiophene-4-carboxylic acid methyl ester are reacted with 1.76 parts by volume of sulfuryl chloride in 50 parts by volume of chloroform in the course of one hour at 0° C. The end product is isolated from the reaction mixture by the method described in Example 1c. 3.64 parts (91% of theory) of 3-acetoxy-thiophene-4-carboxylic acid methyl ester of melting point 56°-58° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04239897 |
| Source dataset | uspto-grants-1980_12 |
| ORD ID | ord-bab7425532424fa7b0f08caf8aea1cfb |
| Source note | uspto-grants-1980_12 |