Sodium Carbonate → N-ethyl-N-[4-(3,4,5-trimethoxybenzoyloxy)butyl]-6-methoxy-1,2,3,4-tetrahydro-2-naphthylamine

Participants

Reaction Steps

Using 2.0 g of N-ethyl-6-methoxy-1,2,3,4-tetrahydro-2-naphthylamine hydrochloride, 3.3 g of 4-iodobutyl 3,4,5-trimethoxybenzoate, 0.9 g of anhydrous sodium carbonate and 40 ml of methyl ethyl ketone, the free base, N-ethyl-N-[4-(3,4,5-trimethoxybenzoyloxy)butyl]-6-methoxy-1,2,3,4-tetrahydro-2-naphthylamine, was obtained using the procedures described in Example 2 (ii). The free base was treated with methanesulfonic acid to obtain 1.5 g of N-ethyl-N-[4-(3,4,5-trimethoxybenzoyloxy)butyl]-6-methoxy-1,2,3,4-tetrahydro-2-naphthylamine methanesulfonate as a pale-yellow oil.

Provenance & Evidence