Bromine → HCID 20303432, compound

Participants

Reaction Steps

20.2 g (100 mmoles) of 4-(pyrazol-1-yl)phenylacetic acid are dissolved in 400 ml of carbon tetrachloride. 16 g of bromine (200 mmoles) in 400 ml of carbon tetrachloride are added dropwise, with ice cooling, to the resulting solution. After subsequent stirring for half an hour at room temperature, washing with sodium dithionite solution is effected; this is followed by drying with sodium sulfate and, finally, by evaporation to dryness to obtain 27.5 g (98% of theory) of 4-(4-bromo-pyrazol-1-yl)phenylacetic acid, m.p. 187° C. (from acetonitrile).

Provenance & Evidence