Sodium Hydroxide → HCID 20303502, compound

Participants

Reaction Steps

4.4 g (17.7 mmoles) of 4-(4-fluoropyrazol-1-yl)phenylacetic acid ethyl ester in 60 ml of 1 N solution of sodium hydroxide are heated to 100° C. for 2 hours. After cooling and extraction with benzene, clarification (effected with activated charcoal) is followed by acidification with concentrated hydrochloric acid to produce 3.7 g (95% of theory) of 4-(4-fluoropyrazol-1-yl)phenylacetic acid, m.p. 165° to 167° C. (from acetonitrile).

Provenance & Evidence