Sodium Hydroxide → HCID 20303454, compound

Participants

Reaction Steps

The crude 2-[4-(pyrazol-1-yl)phenyl]propionic acid ethyl ester from (a) is boiled for 3 hours with 50 ml of 1 N solution of sodium hydroxide, and the thus-obtained solution is extracted with benzene. The aqueous phase is acidified with hydrochloric acid and extracted with benzene. The organic phase is then dried and concentrated; the residue is recrystallized from benzene/cyclohexane (1:1) to yield 1.7 g (80% of theory) of 2-[4-(pyrazol-1-yl)phenyl]propionic acid, m.p. 137° to 138° C.

Provenance & Evidence