1,1,3,3-Tetraethoxypropane → HCID 20303421, compound

Participants

Reaction Steps

41.0 g (186 mmoles) of 1,1,3,3-tetraethoxypropane are added dropwise at 40° C. to 30 g (155 mmoles) of 3-chloro-p-tolylhydrazine hydrochloride in 180 ml of methanol and 15.6 ml of concentrated hydrochloric acid and heated to the boil for 1.5 hours. The resulting solution is concentrated in a vacuum; the thus-prepared concentrate is dissolved in benzene. The obtained benzene solution is washed with water and sodium hydrogen carbonate solution, dried and evaporated to dryness to yield 26 g (87% of theory) of 1-(3-chloro-p-tolyl)pyrazole (m.p. 61° to 62° C.).

Provenance & Evidence