反应详情

252 mg (1 mmole) of 2-[3-chloro-4-(2-pyrazolin-1-yl)phenyl]propionic acid are heated to the boil for 8 hours with 250 mg of active manganese dioxide and 1 g molecular sieve 4 A*) in 10 ml of toluene. Filtration is effected, followed by extraction first with 1 N hydrochloric acid and then with 1 N sodium hydroxide. The aqueous alkaline extract is acidified and subsequently extracted with benzene; the resulting organic phase is dried to yield 2-[3-chloro-4-(pyrazol-1-yl)phenyl]propionic acid (m.p. 83° to 85° C.).

1. filtrationFiltration
2. extractionfollowed by extraction first with 1 N hydrochloric acid
3. extractionThe aqueous alkaline extract
4. extractionsubsequently extracted with benzene
5. customthe resulting organic phase is dried