Ammonia → 2-[3-Chloro-4-(4-chloropyrazol-1-yl)phenyl]propionamide

Participants

Reaction Steps

3 g (10 mmoles) of 2-[3-chloro-4-(4-chloropyrazol-1-yl)phenyl]propionyl chloride are stirred into 30 ml of concentrated aqueous ammonia solution. Stirring is continued for a further half hour at room temperature; adjustment to pH 12 is effected with sodium hydroxide solution, followed by extraction with ether, drying of the ethereal phase and concentration. 2-[3-chloro-4-(4-chloropyrazol-1-yl)phenyl]propionamide (m.p. 131°-132° C.) is obtained.

Provenance & Evidence