反应详情

2.79 g (0.01 mole) of 2-[3-chloro-4-(pyrazol-1-yl)phenyl]propionic acid ethyl ester are dissolved in 30 ml of methylene chloride, and 700 mg of chlorine (dissolved in 5 ml of methylene chloride) are added. Stirring is effected for 12 hours at room temperature, followed by washing of the reaction solution with sodium carbonate solution and water, drying, concentration and distillation. 2-[3-chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic acid ethyl ester is obtained.

1. washby washing of the reaction solution with sodium carbonate solution and water
2. customdrying
3. concentrationconcentration and distillation