Chlorine → 2-[3-Chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic acid ethyl ester

HRID 1733023Notes

Reaction equation

HRID 1733023 reaction equation
[CH2:1]([O:3][C:4](=[O:19])[CH:5]([C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH:17]=[CH:16][CH:15]=[N:14]2)=[C:9]([Cl:18])[CH:8]=1)[CH3:6])[CH3:2].[Cl:20]Cl>C(Cl)Cl>[CH2:1]([O:3][C:4](=[O:19])[CH:5]([C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH:17]=[C:16]([Cl:20])[CH:15]=[N:14]2)=[C:9]([Cl:18])[CH:8]=1)[CH3:6])[CH3:2]

Participants

4

Reactant 2

HCID 24526ChlorineHCID 545042332-[3-Chloro-4-(pyrazol-1-yl)phenyl]propionic acid ethyl ester

Product 1

HCID 539945502-[3-Chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic acid ethyl ester

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.79 g (0.01 mole) of 2-[3-chloro-4-(pyrazol-1-yl)phenyl]propionic acid ethyl ester are dissolved in 30 ml of methylene chloride, and 700 mg of chlorine (dissolved in 5 ml of methylene chloride) are added. Stirring is effected for 12 hours at room temperature, followed by washing of the reaction solution with sodium carbonate solution and water, drying, concentration and distillation. 2-[3-chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic acid ethyl ester is obtained.

Workup

  1. washby washing of the reaction solution with sodium carbonate solution and water
  2. customdrying
  3. concentrationconcentration and distillation

Sources & evidence

ORD record
ord-7626d4870a0942a2942ac3ca39edc92f
Source dataset
uspto-grants-1980_12
Patent number
US04239901

Reaction notes

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