反应详情

2.84 g (0.01 mmole) of 2-[3-chloro-4-(4-chloropyrazol-1-yl) phenyl] propionamide and 1 g (7 mmoles) of phosphorus oxy chloride are heated to 100° C. for one hour. The reaction mixture is cooled, washed with sodium carbonate solution and water, concentrated and distilled. 1.99 g (75%) of 2-[3-chloro-4-(4-chloropyrazol-1-yl) phenyl] propionitrile (b.p. 107°-109° C./10-2 mm Hg) are obtained.

1. temperatureThe reaction mixture is cooled
2. washwashed with sodium carbonate solution and water
3. concentrationconcentrated
4. distillationdistilled