Hydrochloric Acid → 2-[3-Chloro-4-(pyrazol-1-yl)phenyl]propionic acid ethyl ester

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Reaction Steps

2.11 g (8.7 mmoles) of 2-(3-chloro-4-hydrazinophenyl)propionic acid ethyl ester and 1.91 g of tetra-ethoxypropane are dissolved in 2 ml of absolute ethanol. The solution is saturated with hydrochloric acid gas and left to stand for half an hour. The solvent is evaporated off; the residue is distilled. 2 g (83%) of 2-[3-chloro-4-(pyrazol-1-yl) phenyl] propionic acid ethyl ester (b.p. 120° C./10-2 mm Hg) are obtained.

Provenance & Evidence