Iodine → HCID 20303480, compound

Participants

Reaction Steps

340 mg of red phosphorus and 110 mg of iodine are added to 10 ml of glacial acetic acid. After 15 minutes, 2.8 g (0.01 mole) of 4-(4-chloropyrazol-1-yl) mandelic acid are added; heating under reflux is effected for 4 hours, followed by cooling, filtration, pouring on to a sodium sulphite solution and extraction with ether. The ethereal solution is dried and concentrated. 4-(4-chloropyrazol-1-yl) phenylacetic acid (m.p. 176°-178° C.) is obtained.

Provenance & Evidence