Thionyl Chloride → HCID 54401933, compound

HRID 1733028Notes

Reaction equation

HRID 1733028 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[CH:5]([C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH:17]=[CH:16][CH:15]=[N:14]2)=[CH:9][CH:8]=1)O)[CH3:2].S(Cl)([Cl:21])=O>>[CH2:1]([O:3][C:4](=[O:18])[CH:5]([C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH:17]=[CH:16][CH:15]=[N:14]2)=[CH:9][CH:8]=1)[Cl:21])[CH3:2]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 54491804HCID 54491804, compound

Product 1

HCID 54401933HCID 54401933, compound

Procedure

The starting compound is obtained in the following manner: 2.46 g (10 mmoles) of 4-(pyrazol-1-yl) mandelic acid ethyl ester and 10 ml of thionyl chloride are heated to 40° C. for 10 minutes, the excess thionyl chloride is distilled off. α-chloro-4-(pyrazol-1-yl) phenylacetic acid ethyl ester (oil) is obtained.

Workup

  1. customThe starting compound is obtained in the following manner
  2. distillationthe excess thionyl chloride is distilled off

Sources & evidence

ORD record
ord-c39cc3eb5e1c47ec9cbff346cd4d0233
Source dataset
uspto-grants-1980_12
Patent number
US04239901

Reaction notes

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