Water → HCID 54267037, compound

Participants

Reaction Steps

2.65 g of α-chloro-4-(pyrazol-1-yl) phenylacetic acid ethyl ester are dissolved in 50 ml of carbon tetrachloride, and 2 ml of water are added. Chlorine is introduced for 30 minutes and the reaction mixture is washed with sodium carbonate solution; concentration is effected, followed by purification through column chromatography on silica gel. (cyclohexane/diethyl ether 4:1). 4-(4-chloropyrazol-1-yl) phenylglyoxylic acid ethyl ester is obtained which, through saponification analogously to Example 10 is converted into 4-(4-chloropyrazol-1-yl) phenylglyoxylic acid.

Provenance & Evidence