Methyl iodide → HCID 70595015, compound

Participants

Reaction Steps

7.38 g (20 mmoles) of 3-chloro-4-(4-chloropyrazol-1-yl)phenylmalonic acid diethyl ester are dissolved in 20 ml of absolute ethanol; a solution of sodium ethanolate in ethanol (consisting of 470 mg of sodium in 20 ml of ethanol) is added; stirring is effected at 40° C. for half an hour and 2.84 g (20 mmoles) of methyl iodide are added. Boiling under reflux is effected for 4 hours; again, 2.84 g of methyl iodide are added, followed by heating for a further 2 hours, concentration, and taking up with diethyl ether. The ethereal phase is washed with sodium hydrogen sulphite solution and water, dried and concentrated. Methyl-[3-chloro-4-(4-chloropyrazol-1-yl) phenyl] malonic acid diethyl ester is obtained.

Provenance & Evidence