HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 20302326, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | HCID 20302891 | HCID 20302891 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 20302326 | HCID 20302326 | — |
Reaction Steps
24.2 g of 3-(4'-fluoro-4-biphenylyl)-1-buten-3-ol (obtainable from 4-acetyl-4'-fluorobiphenyl and vinylmagnesium bromide) are heated with 8 g of ammonia and 0.25 g of sodium for 8 hours at 180°-200°, and the mixture is cooled and worked up with water and chloroform to give 3-(4'-fluoro-4-biphenylyl)-3-hydroxybutylamine, m.p. 144°-146°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04239759 |
| Source dataset | uspto-grants-1980_12 |
| ORD ID | ord-95db499cedce43ee9b230040ac58de67 |
| Source note | uspto-grants-1980_12 |