HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → HCID 70595686, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Biphenyl | HCID 7095 | — |
| Reactant | 3-Chloropropionyl chloride | HCID 69364 | — |
| Reactant | 1-(biphenyl-4-yl)-3-chloropropan-1-one | HCID 235086 | — |
| Reactant | HCID 70595719 | HCID 70595719 | — |
| Reactant | HCID 70596859 | HCID 70596859 | — |
| Reactant | HCID 86735980 | HCID 86735980 | — |
| Reactant | HCID 178418373 | HCID 178418373 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 70595686 | HCID 70595686 | — |
Reaction Steps
A solution of 2.6 g of 1-chloro-3-p-biphenylylbutan-3-ol [m.p. 68°-70°; obtainable by a Friedel-Crafts reaction of biphenyl with 3-chloropropionyl chloride to give 4-(3-chloropropionyl)-biphenyl and reaction with CH3MgI; or 3.05 g of 1-bromo-3-p-biphenylyl-butan-3-ol or 3.96 g of 1-p-toluenesulfonyloxy-3-p-biphenylyl-butan-3-ol] and 30 g of methylamine in 100 ml of methanol is heated at 120° for 2 hours in an autoclave. After cooling and working up in the customary manner, 1-methylamino-3-p-biphenylyl-butan-3-ol is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04239759 |
| Source dataset | uspto-grants-1980_12 |
| ORD ID | ord-19355569371a40dab5ea24b0c9eccdcd |
| Source note | uspto-grants-1980_12 |