1-Acetamido-3-(4'-fluoro-4-biphenylyl)-butane → 3-(4'-Fluoro-4-biphenylyl)butylamine

HRID 1733063Notes

Reaction equation

HRID 1733063 reaction equation
C([NH:4][CH2:5][CH2:6][CH:7]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)[CH3:8])(=O)C>[OH-].[K+]>[F:21][C:18]1[CH:17]=[CH:16][C:15]([C:12]2[CH:13]=[CH:14][C:9]([CH:7]([CH3:8])[CH2:6][CH2:5][NH2:4])=[CH:10][CH:11]=2)=[CH:20][CH:19]=1

Participants

3

Reactant 1

HCID 203027051-Acetamido-3-(4'-fluoro-4-biphenylyl)-butane

Product 1

HCID 203021083-(4'-Fluoro-4-biphenylyl)butylamine

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

A solution of 28.5 g of 1-acetamido-3-(4'-fluoro-4-biphenylyl)-butane in 800 ml of 10% methanolic KOH solution is boiled for 48 hours. The solution is concentrated and worked up using water and ether to give 3-(4'-fluoro-4-biphenylyl)butylamine; hydrochloride, m.p. 222°-224°.

Workup

  1. concentrationThe solution is concentrated

Sources & evidence

ORD record
ord-c01aa522babf4f9ba0b139561afeb460
Source dataset
uspto-grants-1980_12
Patent number
US04239759

Reaction notes

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