Water → HCID 131711218, compound

Participants

Reaction Steps

38.95 g of 1 -phthalimido-3-(4'-chloro-4-biphenylyl)-butane are boiled with 12.2 ml of 80% hydrazine hydrate in 400 ml of ethanol for 2 hours, while stirring, water is added, the mixture is cooled and the resulting 1-(3,4-dihydro-4-oxo-1-phthalazinyl-amino)-3-(4'-chloro-4-biphenylyl)-butane (m.p. 195°) is filtered off, dissolved in 450 ml of ethanol and 450 ml of 37% hydrochloric acid and boiled for 30 minutes, while stirring. The solution is concentrated and worked up using sodium hydroxide solution and ethyl acetate to give 3-(4'-chloro-4-biphenylyl)-butylamine. Hydrochloride, m.p. 256°-259°.

Provenance & Evidence