17beta,19-Dihydroxy-1alpha,7alpha-dimethyl-4-androsten-3-one dipropionate → 17beta,19-Dihydroxy-1alpha,6alpha-dimethyl-4-androsten-3-one

HRID 1733100Notes

Reaction equation

HRID 1733100 reaction equation
C(O)(=O)CC.C(O)(=O)CC.O[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@]12C)[C@]1(CO)C(=CC(=O)C[C@@H]1C)C[C@H]3C.C(O)(=O)CC.C(O)(=O)CC.[OH:45][C@H:46]1[CH2:51][CH2:50][C@H:49]2[C@H:52]3[C@H:63]([CH2:64][CH2:65][C@:47]12[CH3:48])[C@:60]1([CH2:61][OH:62])[C:55](=[CH:56][C:57](=[O:67])[CH2:58][C@@H:59]1[CH3:66])[C@@H:54]([CH3:68])[CH2:53]3>>[OH:45][C@H:46]1[CH2:51][CH2:50][C@H:49]2[C@H:52]3[C@H:63]([CH2:64][CH2:65][C@:47]12[CH3:48])[C@:60]1([CH2:61][OH:62])[C:55](=[CH:56][C:57](=[O:67])[CH2:58][C@@H:59]1[CH3:66])[C@@H:54]([CH3:68])[CH2:53]3

Participants

3

Reactant 2

HCID 8673473117beta,19-Dihydroxy-1alpha,7alpha-dimethyl-4-androsten-3-one dipropionateHCID 8673569017beta,19-Dihydroxy-1alpha,6alpha-dimethyl-4-androsten-3-one dipropionate

Product 1

HCID 7058393717beta,19-Dihydroxy-1alpha,6alpha-dimethyl-4-androsten-3-one

Procedure

Substituting 17β,19-dihydroxy-1α,7α-dimethyl-4-androsten-3-one dipropionate and 17β,19-dihydroxy-1α,6α-dimethyl-4-androsten-3-one dipropionate in the above procedure results in the preparation of 17β,19-dihydroxy-1α,17α-dimethyl-4-androsten-3-one and 17β,19-dihydroxy-1α,6α-dimethyl-4-androsten-3-one, respectively.

Sources & evidence

ORD record
ord-f006c119497845e9900455f2387b0e3e
Source dataset
uspto-grants-1980_12
Patent number
US04239681

Reaction notes

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