HCID 20300282, compound → HCID 20300249, compound

HRID 1733129Notes

Reaction equation

HRID 1733129 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[N:22]=[C:13]3[C:14]4[C:19]([CH2:20][CH2:21][N:12]3[N:11]=2)=[CH:18][CH:17]=[CH:16][CH:15]=4)[CH:7]=[CH:8][CH:9]=1)([O-])=O>[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([C:10]2[N:22]=[C:13]3[C:14]4[C:19]([CH2:20][CH2:21][N:12]3[N:11]=2)=[CH:18][CH:17]=[CH:16][CH:15]=4)[CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 1

HCID 20300282HCID 20300282, compound

Product 1

HCID 20300249HCID 20300249, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

2-(m-Nitrophenyl)-5,6-dihydro-s-triazolo[5,1-a]isoquinoline (11.7 g.) is hydrogenated at atmospheric pressure and at room temperature in the presence of 3 g. of 10% Pd on charcoal. The product obtained is purified by crystallization from a 50:50 mixture of ethyl acetate and isopropyl ether. Yield 8.5 g. of the title product which melts at 118°-9° C.

Workup

  1. customis hydrogenated at atmospheric pressure and at room temperature in the presence of 3 g
  2. customThe product obtained
  3. customis purified by crystallization from a 50:50 mixture of ethyl acetate and isopropyl ether

Sources & evidence

ORD record
ord-7d0f7eb7bf9f42d0bf6d1e8a694a7af7
Source dataset
uspto-grants-1980_12
Patent number
USRE030456

Reaction notes

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