Methyl Isocyanate → HCID 20300360, compound

HRID 1733141Notes

Reaction equation

HRID 1733141 reaction equation
[CH3:1][N:2]=[C:3]=[O:4].[NH2:5][C:6]1[S:7][CH:8]=[C:9]([CH:13]([CH3:15])[CH3:14])[C:10]=1[C:11]#[N:12]>C1(C)C=CC=CC=1>[C:11]([C:10]1[C:9]([CH:13]([CH3:15])[CH3:14])=[CH:8][S:7][C:6]=1[NH:5][C:3]([NH:2][CH3:1])=[O:4])#[N:12]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 20186668HCID 20186668, compound

Product 1

HCID 20300360HCID 20300360, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

11.8 ml (0.2 mole) of methyl isocyanate were added to a solution of 33.2 g (0.2 mole) of 2-amino-3-cyano-4-isopropyl-thiophene in 200 ml of toluene. After the exothermic reaction had subsided, the product which precipitated in the solid form was filtered off. Further portions of reaction product were obtained by concentrating the mother liquor. 25 g of 1-(3-cyano-4-isopropyl-thien-2-yl)-3-methyl-urea of melting point 179°-181° C. were obtained in this manner.

Workup

  1. customAfter the exothermic reaction
  2. customthe product which precipitated in the solid form
  3. filtrationwas filtered off
  4. customFurther portions of reaction product
  5. customwere obtained
  6. concentrationby concentrating the mother liquor

Sources & evidence

ORD record
ord-5874cbbf46414b6ca2d0eb43cffd9d76
Source dataset
uspto-grants-1980_12
Patent number
US04240820

Reaction notes

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