Acetic Acid → HCID 20300371, compound

HRID 1733148Notes

Reaction equation

HRID 1733148 reaction equation
[NH2:1][C:2]1[O:3][CH:4]=[C:5]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:6]=1[C:7]#[N:8].[C:13](O)(=[O:15])[CH3:14].C(OC(=O)C)(=O)C>>[C:13]([NH:1][C:2]1[O:3][CH:4]=[C:5]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:6]=1[C:7]#[N:8])(=[O:15])[CH3:14]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 7918Acetic AnhydrideHCID 13770581HCID 13770581, compound

Product 1

HCID 20300371HCID 20300371, compoundYield 83.4%

Procedure

16.4 g (0.1 mole) of 2-amino-3-cyano-4-tert.-butylfuran were heated to 100° C. with 24 ml (0.4 mole) of acetic acid and 10.4 ml (0.11 mole) of acetic anhydride for one hour. Thereafter, the reaction mixture was evaporated under reduced pressure and the residue was recrystallized from a mixture of toluene/cyclohexane (1:2). 17.2 g of 2-acetylamino-3-cyano-4-tert.-butyl-furan of melting point 135° C. were obtained in this manner.

Workup

  1. customThereafter, the reaction mixture was evaporated under reduced pressure
  2. customthe residue was recrystallized from a mixture of toluene/cyclohexane (1:2)

Sources & evidence

ORD record
ord-906e8f6c272a4d838725e739580d17b5
Source dataset
uspto-grants-1980_12
Patent number
US04240820

Reaction notes

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