Bromine → HCID 178422369, compound

HRID 1733160Notes

Reaction equation

HRID 1733160 reaction equation
[CH3:1][C:2]1[C:10]([CH3:11])=[CH:9][C:5]2[NH:6][N:7]=[N:8][C:4]=2[CH:3]=1.[Br:12]Br>C(O)(=O)C>[Br:12][C:9]1[C:5]2[N:6]=[N:7][NH:8][C:4]=2[CH:3]=[C:2]([CH3:1])[C:10]=1[CH3:11]

Participants

4

Reactant 2

HCID 24408BromineHCID 178422374HCID 178422374, compound

Product 1

HCID 178422369HCID 178422369, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution of 25.0 grams of 5,6-dimethylbenzotriazole in 250 milliliters of acetic acid at 50° C. is slowly added 30.5 grams of bromine in 75 ml. of the same solvent over a 11/4 hour period. The temperature is held at 50° C. for an additional hour and then the reaction mixture is allowed to cool to room temperature. The product is collected by filtration, 19.2 grams (56%), m.p. 255°-262° C. The analytical sample has a m.p. of 259°-261° C.

Workup

  1. customat 50° C.
  2. custom4 hour period
  3. waitThe temperature is held at 50° C. for an additional hour
  4. filtrationThe product is collected by filtration, 19.2 grams (56%), m.p. 255°-262° C

Sources & evidence

ORD record
ord-0475d44be1454e0987f56747cfe39f4b
Source dataset
uspto-grants-1980_12
Patent number
US04240822

Reaction notes

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