HCID 23461740, compound → HCID 13725072, compound

HRID 1733166Notes

Reaction equation

HRID 1733166 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[NH:16][CH:17]=[CH:18][CH:19]=1)C1C=CC=CC=1>[Pd].CO>[OH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[NH:16][CH:17]=[CH:18][CH:19]=1

Participants

4

Reactant 1

HCID 23461740HCID 23461740, compound

Product 1

HCID 13725072HCID 13725072, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

150 mg of 10% strength palladium-on-charcoal catalyst are added to 1.5 g (6 millimoles) of 2-(o-benzyloxyphenyl) -pyrrole in 30 ml of methanol and hydrogenation is carried out under slightly superatmospheric pressure. The residue which remains after separating off the catalyst and evaporating the filtrate is recrystallized from toluene/petroleum ether (40°/60° C.). the yield is 0.8 g, ie. 84% of theory; melting point 100-101° C.

Workup

  1. customafter separating off the catalyst
  2. customevaporating the filtrate
  3. customis recrystallized from toluene/petroleum ether (40°/60° C.)

Sources & evidence

ORD record
ord-94570814f573442db27c7cb303ed25d5
Source dataset
uspto-grants-1980_12
Patent number
US04240964

Reaction notes

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