HCID 13046999, Verbindung → 8-Chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine

HRID 1733170Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1733170
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH2:12][N+:13]([O-])=[CH:14][CH:10]3[CH2:9][N:8]=[C:7]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[F:22])[C:6]=2[CH:23]=1.CC(C)([O-])C.[K+]>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[N:13][CH:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[F:22])[C:6]=2[CH:23]=1

Komponenten

4

Edukt 2

HCID 13046999HCID 13046999, VerbindungHCID 23665647Potassium tert-butoxide

Produkt 1

HCID 1859468-Chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 50 mg of 8-chloro-6-(2-fluorophenyl)-3a,4-dihydro-1H-imidazo[1,5-a][1,4]benzodiazepine 2-oxide in 3 ml of methanol contianing 25 mg of potassium t-butoxide was heated to reflux for 10 min. The mixture was evaporated partially and the residue was partitioned between methylene chloride and sodium bicarbonate solution. The organic phase was dried and evaporated. Crystallization of the residue from ether yielded product with mp 148°-151° C.

Aufarbeitung

  1. temperatureto reflux for 10 min
  2. customThe mixture was evaporated partially
  3. customthe residue was partitioned between methylene chloride and sodium bicarbonate solution
  4. customThe organic phase was dried
  5. customevaporated
  6. customCrystallization of the residue from ether yielded product with mp 148°-151° C.

Quellen und Nachweise

ORD-Eintrag
ord-dc027eecb7764c0dad35057d02b203f4
Quelldatensatz
uspto-grants-1980_12
Patentnummer
US04240962

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