Sodium Nitrite → HCID 53991132, compound

HRID 1733217Notes

Reaction equation

[Cl:1][CH2:2][CH2:3][NH:4][C:5]([N:7]([CH:19]([CH3:23])[CH2:20][O:21][CH3:22])[CH:8]1[O:16][C@H:15]([CH2:17][OH:18])[C@H:13]([OH:14])[C@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6].[N:24]([O-])=[O:25].[Na+]>>[Cl:1][CH2:2][CH2:3][N:4]([N:24]=[O:25])[C:5]([N:7]([CH:19]([CH3:23])[CH2:20][O:21][CH3:22])[CH:8]1[O:16][C@H:15]([CH2:17][OH:18])[C@H:13]([OH:14])[C@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6]

Participants

Reactant 2

HCID 23668193Sodium Nitrite

HCID 54186845HCID 54186845, compound

Product 1

HCID 53991132HCID 53991132, compoundYield 23.1%

Procedure

3.6 g of 1-(2-chloroethyl)-3-(1-methyl-2-methoxy-ethyl)-3-(D-galactopyranosyl)urea and 1.5 g of sodium nitrite are treated in the same manner as described in Example 24. 0.9 g of 1-(2-chloroethyl)-1-nitroso-3-(1-methyl-2-methoxy-ethyl)-3-(D-galactopyranosyl)urea are thereby obtained as yellow powder.

Sources & evidence

ORD record: ord-c1a3dbc71a5e4b24a6b908f07e99dca7
Source dataset: uspto-grants-1980_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04241053

Reaction notes

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