Water → HCID 178520005, compound

Participants

Reaction Steps

In 50 ml of dry tetrahydrofuran were dissolved 135 mg of the product of Example 6, followed by addition of 2 ml of di-isobutyl-aluminum hydride. The reaction mixture was allowed to stand with dry ice-acetone cooling for 2 hours and then poured into water. The precipitated reagent was removed, the solvent removed by distillation and the residue recrystallized from water-methanol to yield 10 mg of the title compound melting at 290°-295° C. (decomp.). Mol. wt. (based on mass spectrum) 212. IR absorption spectrum: 3300, 1640, 1620, 1600 cm-1. UV absorption spectrum (MeOH): 420, 292, 282, 262 mμ. NMR spectrum (DMSO-d6): 10.1 ppm, 1H (CHO), 7.7 ppm, 1H (4-H), 8.2 ppm, 1H, 7.2-7.6 ppm, 3H.

Provenance & Evidence