Nitrogen oxide (N2O4) → HCID 53970493, compound

HRID 1733250Notes

Reaction equation

HRID 1733250 reaction equation
[Cl:1][CH2:2][CH2:3][NH:4][C:5]([N:7]([CH2:17][C:18]1[S:19][CH:20]=[CH:21][CH:22]=1)[CH:8]1[O:16][CH2:15][C@H:13]([OH:14])[C@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6].[N+:23]([O-])([N+]([O-])=O)=[O:24]>>[Cl:1][CH2:2][CH2:3][N:4]([N:23]=[O:24])[C:5]([N:7]([CH2:17][C:18]1[S:19][CH:20]=[CH:21][CH:22]=1)[CH:8]1[O:16][CH2:15][C@H:13]([OH:14])[C@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6]

Participants

3

Reactant 2

HCID 25352Nitrogen oxide (N2O4)HCID 54427625HCID 54427625, compound

Product 1

HCID 53970493HCID 53970493, compoundYield 81.8%

Procedure

3.5 g of 1-(2-chloroethyl)-3-(thiophen-2-yl-methyl)-3-(L-arabinopyranosyl)urea and 5.0 g of nitrogen tetroxide gas are treated in the same manner as described in Example 31-(2). 3.1 g of 1-(2-chloroethyl)-1-nitroso-3-(thiophen-2-yl-methyl)-3-(L-arabinopyranosyl)urea are thereby obtained as yellow powder.

Sources & evidence

ORD record
ord-b963e26b576f4acfb0a81c249d7180be
Source dataset
uspto-grants-1980_12
Patent number
US04241052

Reaction notes

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