Fenpropidin → 1-[3-(4-Tert.butyl-cyclohexyl)-2-methyl-propyl]-piperidine

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Reaction Steps

7 g of platinum dioxide and 7 g of active carbon are suspended in 500 ml of glacial acetic acid and pre-hydrogenated. Subsequently, a solution of 36.8 g of 1-[3-(p-tert.butyl-phenyl)-2-methyl-propyl]-piperidine in 1000 ml of glacial acetic acid and 67 ml of perchloric acid is added and the mixture is hydrogenated at 25° C. The catalyst is removed by filtration and the filtrate is treated with 110 g of potassium acetate dissolved in 100 ml of water. The precipitated potassium perchlorate is filtered, and the filtrate is evaporated on a rotary evaporator. The crystalline residue is made alkaline with 2-N sodium hydroxide, the free base is extracted with 500 ml of ether, washed neutral with water, dried over sodium sulphate and evaporated. By distillation there is obtained pure 1-[3-(4-tert.butyl-cyclohexyl)-2-methyl-propyl]-piperidine of boiling point 102° C./0.02 Torr.

Provenance & Evidence