2-(4-CHLOROPHENYL)CHROMAN-4-ONE → HCID 12753167, compound

HRID 1733283Notes

Reaction equation

HRID 1733283 reaction equation
ClC1C=CC(C2CC(=O)C3C(=CC=CC=3)O2)=CC=1.Cl.[Cl:20][C:21]1[CH:41]=[CH:40][C:24]([CH:25]2[CH:34]([CH2:35]N(C)C)[C:33](=[O:39])[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[O:26]2)=[CH:23][CH:22]=1>>[Cl:20][C:21]1[CH:22]=[CH:23][C:24]([CH:25]2[C:34](=[CH2:35])[C:33](=[O:39])[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[O:26]2)=[CH:40][CH:41]=1

Participants

3

Reactant 2

HCID 2420652-(4-CHLOROPHENYL)CHROMAN-4-ONEHCID 20301080HCID 20301080, compound

Product 1

HCID 12753167HCID 12753167, compoundYield 35.8%

Procedure

In a similar manner as described in Example 1, 10 g of 4'-chloro flavanone, as described in Bull. Soc. Chim. France 2248 (1963), was converted to 4.0 g of crude 4'-chloro-3-dimethylaminomethyl flavanone hydrochloride. The hydrochloride salt was recrystallized twice from acetone to give 1.1 g of crystals, m.p. 147°-149° C.

Workup

  1. customThe hydrochloride salt was recrystallized twice from acetone

Sources & evidence

ORD record
ord-b84392e646d14323ba94acc24398e728
Source dataset
uspto-grants-1980_12
Patent number
US04241069

Reaction notes

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