Ethanol → HCID 12753177, compound

Participants

Reaction Steps

A mixture of 22.7 g (0.14 mol) of 4-t-butylbenzaldehyde, 19 g (0.14 mol) of 2-hydroxyacetophenone, 38 g (0.1 mol) of borax, 250 ml of H2O and 150 ml of ethanol was refluxed for one day. The reaction was cooled and diluted with an equal volume of H2O and extracted with ether. The ether was washed with brine, dried over anhydrous Na2SO4, filtered, and evaporated to give a brown oil. The oil was chromatographed on 1200 g of silica gel, eluting with benzene. The desired product was obtained as an oil. Recrystallization from petroleum ether gave 2.8 g of 4'-t-butyl flavanone as white crystals, m.p. 103°-104° C.

Provenance & Evidence