Dichloromethane → HCID 12804798, compound

Participants

Reaction Steps

A solution of 3.42 g of 3-(α-phenyl-2-tolyl)pyrrolidine hydrochloride of Example 58 in 50 ml of CH2Cl2 is stirred with an excess of 5% NaOH. The organic phase is separated, washed with water, dried (Na2SO4), and evaporated to an oil. This oil is dissolved in 50 ml of ethyl formate and refluxed for 18 hours. The solvent is removed under reduced pressure to give an oil, which is dissolved in 25 ml of ether, and after cooling 16 hours the product is collected by filtration to provide 1-formyl-3-(α-phenyl-2-tolyl)pyrrolidine, mp 70°-71° C.

Provenance & Evidence