Thionyl Chloride → 2-Bromo-3,3,3-trifluoropropanoyl chloride

HRID 1733339Notes

Reaction equation

HRID 1733339 reaction equation
[Br:1][CH:2]([C:6]([F:9])([F:8])[F:7])[C:3](O)=[O:4].S(Cl)([Cl:12])=O>>[Br:1][CH:2]([C:6]([F:9])([F:8])[F:7])[C:3]([Cl:12])=[O:4]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 136803062-Bromo-3,3,3-trifluoropropanoic acid

Product 1

HCID 540458592-Bromo-3,3,3-trifluoropropanoyl chloride

Procedure

A solution of 2-bromo-3,3,3-trifluoropropanoic acid (5 g.) in thionyl chloride (5 ml.) is refluxed in the steam bath for two hours. The excess thionyl chloride is removed in vacuo, and the residue distilled under reduced pressure to yield 2-bromo-3,3,3-trifluoropropanoic acid chloride.

Workup

  1. customThe excess thionyl chloride is removed in vacuo
  2. distillationthe residue distilled under reduced pressure

Sources & evidence

ORD record
ord-17e0cc6d16604f04b024430f25787f22
Source dataset
uspto-grants-1980_12
Patent number
US04241076

Reaction notes

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