HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diazomethane → HCID 13942746, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | (2S)-1-((benzyloxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid | HCID 12731799 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 13942746 | HCID 13942746 | — |
Reaction Steps
N-Carbobenzyloxy-4-hydroxy-L-proline [12.4 g. (0.047 mole)] is esterified with diazomethane in dioxane-ether as described in JACS, 79, 191 (1957). To avoid freezing of the dioxane the addition of the diazomethane solution is begun at 10° and completed at 0°-2°. The yield of nearly colorless viscous oil is 14.6 g. (100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04241076 |
| Source dataset | uspto-grants-1980_12 |
| ORD ID | ord-b663519934ee4212a3b57e09f4d71135 |
| Source note | uspto-grants-1980_12 |