HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → HCID 73553822, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | (S)-1-((Benzyloxy)carbonyl)-4,4-difluoropyrrolidine-2-carboxylic acid | HCID 53909714 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 73553822 | HCID 73553822 | — |
Reaction Steps
A mixture of 2.4 grams of N-carbobenzyloxy-4, 4-difluoro-L-proline and 12 ml. of hydrogen bromide in acetic acid (30-32%) is stirred for 30 minutes at room temperature and then 300 ml. of anhydrous ether is added. The mixture is cooled and the precipitated solid is filtered and dried under reduced pressure. The desired 4,4-difluoro-L-proline, hydrobromide melts at 163°-165° (s. 160°); [α]D26 -14° (c=1%; methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04241076 |
| Source dataset | uspto-grants-1980_12 |
| ORD ID | ord-10bae7ba40fc41e8a8ddddb52859b125 |
| Source note | uspto-grants-1980_12 |