Dicyclohexylcarbodiimide → HCID 13192709, compound

Participants

Reaction Steps

A solution of 3-(4-methoxybenzyl)thio-2-trifluoromethylpropanoic acid (6.5 g.) and proline tert-butyl ester (3.76 g.) in dichloromethane (500 ml.) is stirred at 0° and treated with dicyclohexylcarbodiimide (4.53 g.) After 30 minutes at 0° and overnight at room temperature, the mixture is filtered and the filtrate is washed neutral. The organic layer is dried and concentrated to dryness in vacuo. The TLC [silica gel methylene chloride/ethyl acetate (95:5)] shows two major spots Rf 0.46 and 0.51 corresponding to the two diastereoisomers.

Provenance & Evidence