化工社化工社 化学情報印刷レポート · 研究参考用
4-Toluenesulfonyl chloride → cis-N-Carbobenzyloxy-4-tosyloxy-L-proline, methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 反応物 | (2S,4S)-1-Benzyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate | HCID 688413 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | cis-N-Carbobenzyloxy-4-tosyloxy-L-proline, methyl ester | HCID 14036189 | — |
反応手順
Following the procedure of Example 19(b), the methyl ester product from part (b) is treated with 12.4 g. of tosyl chloride in 45 ml. of pyridine to give 13.2 g. of cream-colored product; m.p. 114°-117° (s. 105°). 13 g. of this material are recrystallized from 70 ml. of ethanol to 8.4 g. of colorless cis-N-carbobenzyloxy-4-tosyloxy-L-proline, methyl ester; m.p. 133°-135°; [α]D25 -26° (c=1%, chloroform).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04241076 |
| 出典データセット | uspto-grants-1980_12 |
| ORD ID | ord-291d7a927ed04c2781925f8e6d809f78 |
| 出典メモ | uspto-grants-1980_12 |