反应详情

104.5 gm of S-methyl-isothiourea (0.75 mol) and 53.3 gm (1.333 mol) of sodium hydroxide solution are stirred together for 10 minutes in 350 ml of water. 114.5 gm (0.605 mol) of ethyl-ethoxymethylene-nitroacetate are then slowly added thereto, the temperature being kept at 20° C. by cooling. The precipitate is extracted and washed with a little ice-cold water. It is dissolved in approximately 9 liters of hot water and acidified with concentrated hydrochloric acid with cooling. The precipitated product is extracted and washed with ether.

1. custombeing kept at 20° C.
2. temperatureby cooling
3. extractionThe precipitate is extracted
4. washwashed with a little ice-cold water
5. dissolutionIt is dissolved in approximately 9 liters of hot water
6. temperaturewith cooling
7. extractionThe precipitated product is extracted
8. washwashed with ether