Methyl iodide → HCID 178502511, compound

Participants

Reaction Steps

To a solution of 3-iminophenylmethyl-4-(3-carbomethoxythioureido)benzophenone (1.1 g.; 0.0026 mole) in dimethylformamide (10.0 ml.) is added water (3.0 ml.). Additional dimethylformamide (25.0 ml.) is added to dissolve some precipitate and then sodium hydroxide (50% aqueous; 0.21 g.; 0.0026 mole) is added. The resulting solution is stirred at room temperature for 11/2 hours and then methyl iodide (0.38 g.; 0.0026 mole) is added. The solution is stirred for one hour at room temperature and then poured into water (250 ml.). The precipitate is collected by filtration and dried to afford 0.95 g. of 3-iminophenylmethyl-4-(3-carbomethoxy-S-methylisothioureido)benzophenone, m.p. 140°-142° C. (dec.).

Provenance & Evidence