Dimethyl Sulfoxide → HCID 178502518, compound

Participants

Reaction Steps

To 100.0 g (0.33 mole) of imino(2-furylmethyl)-2-(3-carbomethoxythioureido) benzene and 50.0 g. (0.395 mole) of benzyl chloride in 275 ml. of dimethyl sulfoxide is slowly added 15.0 g (0.375 mole) of sodium hydroxide in 260 g. of water. The resulting mixture is stirred for 1/2 hour and the yellow precipitate is separated by filtration and recrystallized from 800 ml of methylene chloride-hexane (1:1) to give 91.1 g (70.1%) of 1-imino-(2-furylmethyl)-2-(3-carbomethoxy-S-benzylisothioureido)benzene m.p. 112°-114° C.

Provenance & Evidence