Methanol → HCID 86737400, compound

HRID 1733380Notes

Reaction equation

HRID 1733380 reaction equation
[C:1]([NH:5][C:6](=[S:19])[NH:7][C:8]1[CH:14]=[C:13]([S:15][CH2:16][CH2:17][CH3:18])[CH:12]=[CH:11][C:9]=1[NH2:10])([O:3][CH3:4])=[O:2].[CH3:20][C:21]1[CH:28]=[CH:27][C:24](C=O)=[CH:23][CH:22]=1.[CH3:29]O>>[NH:10]=[C:9]1[CH:11]=[CH:12][C:13]([CH3:29])([S:15][CH2:16][CH2:17][CH3:18])[C:14]([CH2:20][C:21]2[CH:28]=[CH:27][CH:24]=[CH:23][CH:22]=2)=[C:8]1[NH:7][C:6]([NH:5][C:1]([O:3][CH3:4])=[O:2])=[S:19]

Participants

4

Reactant 3

HCID 887MethanolHCID 77254-MethylbenzaldehydeHCID 20301198HCID 20301198, compound

Product 1

HCID 86737400HCID 86737400, compoundYield 89%

Conditions

Temperature
10 °C

Procedure

To a suspension of 2-(3-carbomethoxythioureido)-4-propylthioaniline (9.0 g; 0.03 mole) in methanol (100 ml), cooled to 10° C., there is added p-methylbenzaldehyde (3.6 g; 0.03 mole). The mixture is stirred at 10° C. for 1 hr. and at room temperature for 18 hrs. The suspension that forms is vacuum filtered and the filter cake is air dried to afford 1-imino(4-methyl)phenylmethyl-2-(3-carbomethoxythioureido)-4-propylthiobenzene (10.75 g; 89%), m.p. 135°-141° C.

Workup

  1. waitand at room temperature for 18 hrs
  2. filtrationfiltered
  3. customdried

Sources & evidence

ORD record
ord-882ae2bc61df4968b5afb9e4c8cfa1b9
Source dataset
uspto-grants-1980_12
Patent number
US04241079

Reaction notes

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