Acetone → HCID 178460822, compound

Participants

Reaction Steps

A mixture of 1-imino-(4-nitro)phenylmethyl-2-(3-carbomethoxythioureido)-4-propylthiobenzene (4.3 g; 0.01 mole) acetone (50 ml), water (25 ml) and 50% aqueous sodium hydroxide (0.8 g; 0.01 mole) is stirred at room temperature for 15 min. and is cooled to 12° C. To the mixture there is added methyl iodide (1.4 g; 0.01 mole) and it is stirred at 13° C. to 20° C. for 2 hrs. The suspension that forms is vacuum filtered and the filter cake is washed with acetone and dried to afford 1-imino(4-nitro)phenylmethyl-2-(3-carbomethoxy-S-methylisothioureido)-4-propylthiobenzene (3.5 g; 78%), m.p. 135°-137° C. dec.

Provenance & Evidence